PatchMD's Menopause Day Relief patches are the best all-in-one method on the market for alleviating your menopause symptoms. Made with all natural ingredients, each patch provides instant & long lasting relief from mood swings, hot flashes, vaginal dryness, headaches, & heart palpitations. Convenient once-a-day application. Patches should be worn for 8 hours in an area with little or no hair (such as your shoulder, back, or hip). Avoid using lotion or cream that may inhibit absorption of the area. Patch is not waterproof and it is okay to wear multiple at a time but there is no additional benefit to wearing the patch longer than 8 hours. Each pack has a 30 day supply. It is not recommended to wear Day Relief at night as it may keep you awake.